CareLit Fachartikel
Purifikation, Charakterisierung und biologische Wirkungen von alpha-Amylase-/Trypsininhibitoren aus Pflanzen, Effektoren von intestinalen TLR4 bei Zöliakie
V Zevallos, Y Junker, M Laparra, B Hebich, N Rüssel, D Schuppan · Zeitschrift für Gastroenterologie · 2012 · Heft 08
Dokument
1110794
CareLit-ID
Jahr
2012
Publikation
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Zusammenfassung
Aims: The family of cereal alpha-amylase/trypsin inhibitors (ATIs), pest resistance molecules of grains, has been implicated in the development of allergic responses. We have identified wheat ATIs (CM3 and 0.19) as potent activators of innate immunity in celiac disease by engaging the toll like receptor 4 (TLR4)-MD2-CD14 complex in monocytes, macrophages and dendritic cells. ATIs are also present in other plants but have not been evaluated in relation to innate immune activation. Objective: To extract, purify and characterize ATIs from cereals, grains and legumes and to evaluate their ability to stimulate innate…
Schlagworte
Alpha-Amylase
Autoimmune Diseases
Dendritic Cells
Cytokines
Cytokine
After
Zeitschrift für Gastroenterologie
