Effect of HCV core gene of genotype 3a on HCV induced oxidative stress, steatosis and Apoptosis leading to HCC

Hepatitis C virus (HCV) has become a major threat for global health. HCV genes are thought to activate multiple signaling pathways and play a significant role in the alteration of cellular gene expression responsible for HCV pathogenesis leading to hepatocellular carcinoma (HCC). HCV is genetically highly variable and exist as different genotypes and subtypes, the severity of effect within subtypes and major genotype is diverse. However, the molecular mechanism of HCV genome-specific pathogenesis still remains unclear. So it is crucial to study the cross talk between HCV genes of different genotypes and host fac…