A novel splice variant of calcium and integrin binding protein 1 mediates protein kinase D2 stimulated tumour growth and angiogenesis

Protein kinase D2 (PKD2) is a member of the PKD family of serine/threonine kinases, a subfamily of the CAMK super-family. PKDs play a critical role in cell motility, migration, and invasion of cancer cells. Expression of PKD isoforms is deregulated in various tumours and PKDs, in particular PKD2, have been implicated in the regulation of tumour angiogenesis. In the present study, we aimed at further defining the role of PKD2 in tumours. We searched for novel PKD2 substrates that could play a role in angiogenesis using in vitro expression cloning and identified a novel splice variant of human Calcium and Integrin…