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Quantitative differences in binding of a fluorescent bisphosphonate to bone minerals are observed in mouse models of bone turnover: potential for application as an imaging probe f…

S Tiwari, R Tower, GM Campbell, F Grundmann, N Purcz, O Gavrilova, M Müller, C Schem, CC Glueer · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2012 · Heft 11

Dokument
1111000
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Jahr
2012
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren
Autor:innen
S Tiwari, R Tower, GM Campbell, F Grundmann, N Purcz, O Gavrilova, M Müller, C Schem, CC Glueer
Ausgabe
Heft 11 / 2012
Seiten
–
Erschienen: 2012-11-30 00:00:00
ISSN
1438-9029
DOI
10.1055/s-0032-1329747

Zusammenfassung

Aim: To establish an in-vivo assay which could quantitatively detect changes in bone metabolism. Such an imaging tool would also be useful in monitoring efficacy of new therapies in bone metastases. Material und Methods: Osteosense750 (Perkin Elmer), a fluorescent bisphosphonate, was injected into overectomized (OVX) mice (bone loss) and following parathyroid hormone (PTH) treatment (bone gain). The fluorescent signal at the knee region of the hind legs and the spine was collected using an optical imaging device (FMT2500LX, Perkin Elmer). Parallel micro-CT scans (vivaCT40, Scanco Medical) were performed to confi…

Schlagworte

Optical Imaging bone metabolism bisphosphonate Binding Osteosense750 Assay Kinetics Fluorescent Models Imaging Changes Efficacy Perkin Elmer Treatment RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Ver…