Respiratory movement correction through object tracking in perfusion imaging of lung tumours: Proof of principle
M Tepper, H Knabe, J Borggrefe, M Heller, C Hintze, J Biederer, A Wulff · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2012 · Heft 11
Bibliografische Angaben
Zusammenfassung
Zielsetzung: Therapy assessment in solid tumours is moving away from morphologic criteria (e.g. RECIST) to functional imaging of biological effects of new drugs (e.g. VEGF inhibitors). Respiratory motion is a challenge to imaging of microvascular properties in lung tumours. Material und Methodik: We simulated a hemithorax of 50 patients with a round tumour in a software phantom. Respiratory motion was induced as sinusoidal coordinate shift of the tumour. Contrast agent bolus passage through the tumour was modelled as density change over time based on two gamma functions (ground truth). Tracking was performed by…
