CareLit Fachartikel
Alternative screening assay to beryllium lymphocyte proliferation test for identification of beryllium sensitization – Pilot study
C Moeller, G Zissel, M Ernst, J Müller-Quernheim, KI Gaede · Pneumologie · 2012 · Heft 11
Dokument
1111007
CareLit-ID
Jahr
2012
Publikation
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DOI
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Zusammenfassung
Sarcoidosis is a rare interstitial lung disorder of unknown aetiology. In contrast, chronic beryllium disease (CBD), which is clinically indistinguishable from sarcoidosis, is induced by occupational beryllium exposure. In both disorders the primarily affected organ is the lung. The only applicable hallmark to differentiate sarcoidosis from CBD is the presence of beryllium specific T cells defined as beryllium sensitization (BeS) which is a prerequisite for clinical manifestation of CBD. To date the only assay to detect BeS is the beryllium lymphocyte proliferation test (Be-LPT) which measures the capability of…
Schlagworte
Beryllium
Blood
Bronchoalveolar Lavage
Blood Cells
Work
After
Pneumologie
