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Intrapulmonary delivery of human umbilical cord mesenchymal stem cells attenuates acute lung injury by expanding CD4+CD25+forkhead boxp3 (FOXP3)+regulatory T cells and balancing a…

R Wu, J Sun, ZC Han · Klinische Pädiatrie · 2012 · Heft 11

Dokument
1111020
CareLit-ID
Jahr
2012
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
R Wu, J Sun, ZC Han
Ausgabe
Heft 11 / 2012
Seiten
–
Erschienen: 2012-11-30 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0032-1330787

Zusammenfassung

Background: Systemic and local inflammatory processes have a key, mainly detrimental role in the pathophysiology of acute lung injury (ALI). The present study was designed to determine whether human umbilical cord mesenchymal stem cells (UCMSC) are able to act on CD4+CD25+Foxp3+Treg cells and lead to an improvement in ALI. Methods: Mice were administered intratracheally endotoxin (lipopolysaccharide [LPS]) and received intrapulmonary 1×106 UCMSC 4 hours after challenge. The CD4+CD25+ Foxp3+Treg, survival time, body weight, histology and lung injury scores were assessed after transplantation of UCMSC. In addition…

Schlagworte

Acute Lung Injury Transplantation After Lead Tumor Klinische Pädiatrie