Metabolic signature of electrosurgical liver dissection
W von Schönfels, O von Kampen, E Patsenker, F Stickel, B Schniewind, S Hinz, M Ahrens, K Balschun, J Egberts, K Richter, A Landrock, B Sipos, O Will, P Huebbe, S Schreiber, M Nothnagel, C Röcken, G Rimbach, T Becker, J Hampe, C Schafmayer · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background and Aims: High frequency electrosurgery has a key role in the broadening application of liver surgery. Its molecular signature, i.e. the metabolites evolving from electrocauterization which may inhibit hepatic wound healing, have not been systematically studied. Methods: Human liver samples were thus obtained during surgery before and after electrosurgical dissection and subjected to a two-stage metabolomic screening experiment (discovery sample: N=18, replication sample: N=20) using gas chromatography/mass spectrometry. Results: In a set of 208 chemically defined metabolites, electrosurgical dissecti…
