Metabolic reprogramming of liver cancer metabolism by the MYC oncogene

Background: Hepatocellular carcinoma (HCC) is among the three leading causes of cancer-related death. HCC is often attributed to multiple etiologies and affects diverse populations worldwide. HCC usually presents with a poor prognosis and six months median survival. Currently, except for early surgical intervention or liver transplantation, no effective cures exist. Despite its significance, a clearer understanding of mechanisms of liver cancer pathogenesis is limited. The temporal relationship between oncogene signaling, in vivo tumor formation and metabolic pathways is poorly understood. The MYC oncogene has p…