Down regulation of Sonic Hedgehog Signaling attenuates carcinogenesis in vitro and increased tumor necrosis in a Xenograft mouse model of cholangiocellular carcinoma
M El Khatib, A Kalnytska, V Palagani, U Kossatz, MP Manns, NP Malek, L Wilkens, RR Plentz · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background: The Hedgehog signaling pathway controls cell proliferation and differentiation during embryonic development. Altered activation of Hedgehog has been found and described in different human tumor types. Cholangiocellular carcinoma (CCC) is the second most common primary malignant tumor in the liver. The vast majority of patients with CCC are not good candidates for curative surgery and conventional chemotherapeutic drugs are limited. In this study, we investigated the effects of Hedgehog inhibition by Cyclopamine and 5E1 in cultured human CCC cell lines and in vivo using a Xenograft mouse model. Method…
