Accelerated Growth of Colorectal Liver Metastasis following Partial Hepatectomy

Introduction: Nearly 50% of colorectal cancer patients develop metastatic liver tumours. Even after complete resection of the affected liver segments, 5-year survival rates border on only 30%. Micrometastases and dormant tumour cells may rapidly further develop into tumour masses. Following partial hepatectomy (PH), regenerative processes initiate, leading both to the restoration of liver parenchyma as well as the undesirable proliferation of tumour cells. This work aims to investigate the influence of PH on the growth and composition of colorectal liver metastasis in a syngeneic rat model. Materials and Methods…