CareLit Fachartikel
Reversing chemotherapy resistance of liver cancer stem cells through inhibition of Il8 signalling
B Wolf, C Falk, L Wilkens, NP Malek, U Kossatz-Böhlert · Zeitschrift für Gastroenterologie · 2013 · Heft 01
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1111287
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2013
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Zusammenfassung
Background and aims: We recently identified a mechanism by which a hepatic stem cell is turned into a tumor stem cell (Kossatz et al, JCI 2010). These tumor stem cells form chemotherapy resistant tumors in nude mice. To analyze if extrinsic factors may contribute to chemotherapy-resistance we used a chemokine array and found that KC the mouse homologue of human IL8 is secreted in significant amounts by liver cancer stem cells. In HCC patients increased IL 8 levels correlate with tumor size and stage as well as patients survival. Objectives: The aim of our studies was to determine the effects of KC signaling on g…
Schlagworte
Tumor
Chemokine
Cytokine
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Work
Zeitschrift für Gastroenterologie
