Inhibitory receptor expression and phenotype of virus-specific T cells are linked to tissue localization and HCV control
DC Kroy, D Ciuffreda, J Cooperrider, M Tomlinson, GD Hauck, J Aneja, CT Berger, K Tanabe, N Elias, G Freeman, R De Kruyff, J Misdraji, AY Kim, GM Lauer · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background and specific aims: Increased co-expression of PD-1 with other T cell inhibitory receptors is a hallmark of T cell exhaustion, but important questions remain about the relationship between inhibitory receptor expression patterns and the ability of T cells to control viral infections. Furthermore, human studies have been mostly limited to the analysis of T cells in the blood, which might not reflect the situation at the site of HCV infection – the liver. Therefore, the aim of this study is to compare the expression of T cell regulatory molecules on bulk and virus-specific T cells in blood and liver and…
