Attenuated allergic airway inflammation in Cd39-/- mice
M Idzko, K Ayata, T Müller, T Dürk, M Grimm, K Baudiß, RP Vieira, S Cicko, A Zech, S Sorichter, J Pelletier, J Sévigny, S Robson · Pneumologie · 2013 · Heft 02
Bibliografische Angaben
Zusammenfassung
Rationale: Extracellular ATP accumulates in the lung following allergen challenge and contributes, via activation of purinergic receptors on dendritic cells (DC), to the development of allergic airway inflammation (AAI). ATP-levels in the airways are normally tightly regulated by CD39 ectonucleotidase that is highly expressed in several tissues including skin and bone marrow DC. CD39 has been shown to modulate DC adaptive/haptenic immune responses. Objectives: To evaluate the impact of altered purinergic signaling on myeloid DC on AAI using Cd39 deficient mice. Methods: OVA-alum and house dust mite (HDM) bone ma…
