Humoral factors by bone marrow-derived MSC enhance survival of injured β-cells by preserving AKT signalling
C Liu, L Lang, C Jäger, J Baumann, M Schmid, AE Mehana, M Alt, S Sojka, N Perakakis, K Laubner, G Päth, J Seufert · Diabetologie und Stoffwechsel · 2013 · Heft 04
Bibliografische Angaben
Zusammenfassung
Introduction: Our previous work has verified in vitro that human bone marrow-derived MSC with telomerase overexpression (hMSC-TERT) migrate towards injured rat INS-1E β-cells and increase their viability. Both cell lines were considered a valid model since they closely resemble primary rat (plastic-adherent) MSC and islets. Here we investigated whether humoral factors by cocultured hMSC-TERT reduce apoptosis and induce proliferation in INS-1E. Since AKT signalling plays a very central role for survival and proliferation in β-cells, we further analysed whether humoral hMSC-TERT-derived factors rescue p-AKT levels…
