Effect of nocturnal oxygen and acetazolamide on exercise performance in patients with precapillary pulmonary hypertension and sleep disturbed breathing. Randomized, double-blind,…

Objectives: To test whether nocturnal oxygen therapy (NOT) or acetazolamide improve exercise performance and quality of life in patients with precapillary pulmonary hypertension (PH) and sleep disturbed breathing (SDB). Aims: SDB is common in PH and impairs daytime performance. The efficacy of oxygen and acetazolamide have not been tested in this setting. Methods: This was a randomized, placebo-controlled, double-blind, cross-over trial. Participants received NOT (3 l/min), acetazolamide tablets (2 × 250 mg), and sham-NOT/placebo tablets each during 1 week with 1-week washout between treatments periods. 23 patie…