NIR-Emissive Nanosensors for oxygen sensing in tumors
J Napp, T Behnke, L Fischer, Ch Würth, M Wottawa, DE Katschinski, F Alves, U Resch-Genger, M Schäferling · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2013 · Heft 04
Bibliografische Angaben
Zusammenfassung
Ziele: Hypoxia is one of the major attributes of solid tumors, caused by a combination of an increased oxygen consumption and usually insufficient oxygen supply. Therefore, there is a high demand for sensitive and cost effective tools for the determination of tumor oxygenation in vivo and in real time. Here, we present the development and the first in vitro and in vivo application of NIR-emissive polystyrene nanobeads with high potential for measurements of the tumor oxygen levels in vivo. Methode: 100 nm polystyrene nanoparticles were dopes with an oxygen-sensitive phosphorescent Pd(II) porphyrin and an innert…