Hematologic and hemodynamic effects of splenectomy on cirrhotic and non-cirrhotic portal hypertensive rats
P Schwabl, BA Payer, TL Schubert, F Riedl, M Wagner, L Garnys, AI Schiefer, T Reiberger, M Peck-Radosavljevic · Zeitschrift für Gastroenterologie · 2013 · Heft 05
Bibliografische Angaben
Zusammenfassung
Introduction: Potential mechanisms leading to leucopenia, anemia and thrombocytopenia in cirrhosis and portal hypertension (PHT) remain to be explored in well-defined animal models. Methods: Male Sprague-Dawley rats underwent partial portal vein ligation (PPVL; n = 18) to induce PHT, bile duct ligation (BDL; n = 12) to induce cirrhotic PHT or sham-operation (SO; n = 24). Additionally PPVL (n = 21), BDL (n = 12) or SO (n = 23) were combined with splenectomy (SPLECT). Hemodynamic measurements including mean arterial pressure (MAP), heart rate (HR), and portal pressure (PP) were performed 1 – 35 days afterwards. He…
