Effects of non-conjugated bile acid on the acid-base transporters of the human esophageal epithelial cells
D Laczkó, V Venglovecz, P Hegyi, Z Rakonczay, F Izbéki, R Róka, T Wittmann, A Rosztóczy · Zeitschrift für Gastroenterologie · 2013 · Heft 05
Bibliografische Angaben
Zusammenfassung
Introduction: Barrett's esophagus (BE) is the most severe complication of gastro-esophageal reflux disease (GERD). Exposure of gastric and/or bile acids during reflux episodes play a critical role in the pathogenesis of BE. The acid extruding mechanims of esophageal epithelial cells (EECs) are not completely understood, although the acid-base transporters may play an important role against these toxic agents. The aim of our study was to investigate the effects of bile acids on human EECs. Methods: CP-A esophageal epithelial cell line was derived from a region of non-dysplastic metaplasia of BE and grown to confl…
