From add-on cobination therapy to mono-therapy in treatment experienced CHB patients with viral resistance or partial responses: Results from an international mulicentre cohort st…
J Petersen, S Unger, M Buti, M Lütgehetmann, P Lampertico, C Sarrazin, P Buggisch · Zeitschrift für Gastroenterologie · 2013 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background and aim: Long-term viral suppression is a major goal to prevent disease progression in patients with chronic hepatitis (CHB). Aim of this ongoing cohort study is to investigate the safety and efficacy of mono-therapy with entecavir (ETV) or tenofovir (TDF) following a long-term rescue combination-therapy with ETV plus TDF in 23 CHB patients who were only partial responders or multidrug resistant. Methods: Open label cohort study, investigator initiated, from 5 European centres. Patients were only included with suppressed viremia (LLoD < 69 IU/ml) for > 12 months during ETV plus TDF rescue combination…
