CareLit Fachartikel

M65 is a highly sensitive marker of alcoholic steatohepatitis

S Mueller, E Yagmur, F Stickel, HK Seitz, T Longerich, H Bantel · Zeitschrift für Gastroenterologie · 2013 · Heft 08

Dokument
1112020
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Jahr
2013
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
S Mueller, E Yagmur, F Stickel, HK Seitz, T Longerich, H Bantel
Ausgabe
Heft 08 / 2013
Seiten
–
Erschienen: 2013-08-16 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0033-1352767

Zusammenfassung

Aim: The non-invasive assessment of disease activity in patients with non-alcoholic and alcoholic liver disease (NALD and ALD) is still unsettled but essential for the evaluation of disease progression. We here studied dependence of total (M65) and caspase-cleaved (M30) cytokeratin-18 fragments on histological subscores of inflammation, fibrosis and steatosis and the role of alcohol detoxication. Methods: M30 and M65 (ELISA, Peviva, Sweden) were measured in patients with biopsy-proven ALD (n = 105) and NALD (n = 30). The natural course of M30 and M65 levels upon alcohol detoxication was studied in 40 patients. R…

Schlagworte

Biopsy Zeitschrift für Gastroenterologie