In vivo imaging and targeted siRNA delivery using superparamagnetic nanoparticles (MNPs) in pancreatic ductal adenocarcinoma

Aim: Pancreatic ductal adenocarcinoma is one of the most aggressive and deadly malignancies. Despite considerable knowledge about the cell biology and the genetic changes of malignant cells, therapeutic options for pancreatic adenocarcinoma remain ineffective. One plausible explanation for the poor tumor response to therapy is an insufficient delivery of anticancer drugs to the tumour site. Superparamagnetic nanoparticles (MNPs) could serve a dual purposes: the can delivery antiproliferative substances to turmour cells and they allow for noninvasive assessment of this delivery by in vivo MRI. Results: We synthes…