A common variant of PPARgammaPro12Ala correlates with the clinical outcome of pancreatic cancer patients

Recently published genome-wide association studies (GWAS) have identified a number of common genetic variations associated with susceptibility to pancreatic ductal adenocarcinoma (PDAC), which can be mapped to core cancer signaling of PDAC. The peroxisome proliferator-activated receptor gamma (PPARgamma) signaling has been shown to be associated with various aspects of PDAC and a common variant of PPARgammaPro12Ala has been proposed as a novel risk allele. Thus, we aim to explore the clinical relevance of PPARgammaPro12Ala in a cohort of PDAC patients. In order to examine the frequency of PPARgammaPro12Ala in PD…