CareLit Fachartikel
Airway region-specific effects of carbon black nanoparticles (CBNP)
S Schlick, J Kopf, M Ströbele, H Fehrenbach · Pneumologie · 2013 · Heft 12
Dokument
1112192
CareLit-ID
Jahr
2013
Publikation
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Metadaten
DOI
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Zusammenfassung
CBNP are found in industrially produced carbon black which is preferably used for reinforcement of elastomers (e.g. in tyres) but are also present in paints, toner and batteries. CBNP may have lung cytotoxic and pro-inflammatory effects. The commercially available CBNP Printex 90 (P90) as well as the quartz DQ12 were shown to possess cytotoxic and pro-inflammatory properties in mice and human epithelial cell lines. We sought to investigate whether these particles exert similar effects in distal versus proximal airway explants of mice. Further, we investigated whether surface modifications with cancerogenic PAHs…
Schlagworte
After
Benzo(a)pyrene
Acetylene
Cytokine
Lead
Pneumologie
