Beneficial effects on weight gain, hepatic steatosis and expression of lipogenic target genes in a murine obesity model after IL-1 type cytokine inactivation
J Wohlfahrt, A Fettelschoss, T Kündig, H Hermanns, B Müllhaupt, J Schmitt, A Geier · Zeitschrift für Gastroenterologie · 2014 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease worldwide and its prevalence is still increasing. NAFLD affects up to one fourth of the normal population and 50 – 75% of these patients are also suffering from obesity or type II diabetes. Although the pathogenesis is yet poorly understood recent studies show that inflammatory cytokines and especially IL-1 alpha and beta play a crucial role in the development of the disease. The overall purpose of this project is to clarify the pathophysiological effect of IL-1 in hepatic lipid accumulation and to asse…
