Effect of direct single-dose irradiation on fat metabolism in rat liver: FAT/CD36 as the main responsible protein?

Introduction: The liver is a very radiosensitive organ in which processes are initiated early in time which can lead to impairment of liver function. Because the liver is the main metabolism organ of the body, it is necessary to characterize a negative impact on liver function triggered by radiation exposure. A rat model of acute Hepatosteatosis by single-dose liver irradiation was developed to examine histological changes and altered gene expression at early time points. Methods: A single dose of 25 Gy was selectively given to rats with liver on focus. The rats were sacrificed humanly and liver organs were remo…