Decreased phosphorylated Smad3 at linker site predicts poor prognosis of patients with cholangiocarcinoma
HL Weng, S Munker, I Koenigsrainer, B Sipos, A Koenigsrainer, S Nadalin, S Dooley, J Li · Zeitschrift für Gastroenterologie · 2014 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background & Aims: Phosphorylation at C-terminal and linker sites of Smad3 by TGF-β or other factors plays different roles in carcinogenesis. The present study investigated the potential association between phosphorylation at C-terminal/linker sites of Smad3 and clinical characteristics of intrahepatic cholangiocarcinoma (ICC). Methods: Immunohistochemistry (IHC) staining was performed to detect the levels of TGF-β, p-Smad3C, p-Smad3L(ser204, ser208 and ser213) and cytokeratin19 (CK19) in 40 resected specimens (25 ICC, 10 cirrhosis and 5 hemangioma). The correlation between TGF-β/Smad3C IHC score and clinicopath…
