In vivo RNAi screen for new tumor suppressor genes in Hepatocellular Carcinoma

The protooncogene c-Myc is a tightly regulated transcription factor in normal cells and deregulated c-Myc plays a significant role in the development of human cancers and is overexpressed in a wide range of human tumors like in human hepatocellular carcinoma (HCC) (50%). Hepatocellular carcinoma constitutes the third most common cause of cancer related death worldwide, a fact that is also largely attributed to the lack of effective treatment options. The multikinase inhibitor Sorafenib represents the first systemic treatment resulting in 2.8 month prolonged survival highlighting the need of a better understandin…