Hepatitis C virus induced suppression of IκBζ and interference with IκBζ induced Lipocalin2 Expression

Every year, 3 – 4 million people are infected with the Hepatitis C virus (HCV). In more than 70% the infection becomes chronic and leads to complications like liver failure, end stage cirrhosis or Hepatocellular Carcinoma. More than 350 000 people die every year from HCV. In recent years it became more and more evident that HCV broadly interacts with key pathways of its host cell and has evolved strategies to influence processes such as cell proliferation, cell differentiation, apoptosis but also the intercellular communication within its host. One of these key pathways influenced by the virus are signal-transdu…