Quantification of Large, Middle and Small Hepatitis B virus (HBV) surface protein (HBsAg) fractions in patients with Hepatitis Delta
SB Wiegand, B Bremer, A Geipel, CM Bremer, A Wranke, B Heidrich, MP Manns, H Wedemeyer, D Glebe, M Cornberg · Zeitschrift für Gastroenterologie · 2014 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background and aims: HBsAg itself is regarded as the sum of three HBV-surface-proteins present on virions and subviral particles. They are co-carboxyterminal proteins called large (L-), middle (M-) and small (S-)HBs that differ in aminoterminal sequences and glycosylation status (preS1/preS2 in LHBs; N-glycosylated preS2 in MHBs, SHBs in all proteins). Commercial HBsAg-tests can only determine the total amount of HBsAg but variations in their protein composition and posttranslational modifications are not covered that could reflect specific host responses, since preS-domains cover B-and T-cell epitopes. LHBs con…
