The MAPKAP kinase 2 controls IL-10 expression and protects from liver injury upon cytomegalovirus infection
C Ehlting, M Trilling, C Tiedje, A Zimmermann, VTK Le, M Gaestel, H Hengel, D Häussinger, JG Bode · Zeitschrift für Gastroenterologie · 2014 · Heft 01
Bibliografische Angaben
Zusammenfassung
The anti-inflammatory cytokine IL-10 inhibits the activity of Th1 cells, NK cells and macrophages, which are required for optimal pathogen clearance, but also contribute to tissue damage during infection. Cytomegalovirus (CMV) infection induces the expression of IL-10 to limit immune cell activation and to suppress IFNγ induced MHC class II surface expression, thereby escaping anti-viral mechanisms and diminishing the pro-inflammatory response. This appears to be of particular importance for the prevention of CMV-induced liver injury as suggested from studies on IL-10-deficient mice, which upon infection with MC…
