Polarized Secreted IL-17C Mediates Respiratory Epithelial Innate Immune Response

Einleitung: Recent studies showed that IL-17C is expressed by epithelial cells and stimulates the release of antimicrobial factors and inflammatory mediators in target cells. In this study, our aim was to examine the expression and function of IL-17C in polarized respiratory epithelial cells during bacterial infection. In vitro studies showed that common bacterial pathogens, such as (P. Aeruginosa) induced the expression and release of IL-17C in human respiratory epithelial cells and in the Calu-3 cell line in a polarized manner. Methoden: Primary human bronchial epithelial cells and Calu-3 cells were cultured w…