CareLit Fachartikel
Improving Diagnostic Methods for Minimal Residual Disease Detection (MRD) in Childhood Acute Lymphoblastic Leukemia (ALL)
A Szymansky, S Groeneveld-Krentz, J Hof, R Kirschner-Schwabe, C Eckert · Klinische Pädiatrie · 2014 · Heft 05
Dokument
1113409
CareLit-ID
Jahr
2014
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben
Zusammenfassung
Introduction: Our group has shown the high frequency and the prognostic value of IKZF1 deletions and TP53 alterations in relapsed childhood ALL. Interestingly, IKZF1 deletions and TP53 alterations predicted subsequent relapses among patients with MRD good response. We wanted to test the hypothesis whether the use of these two functional markers for MRD quantification provide additional information about the kinetics of the subsequent relapse driving clone. Methods: For MRD quantification, IKZF1 and TP53 specific real-time quantitative (RQ) PCR targeting intragenic consensus breakpoints are used and point mutatio…
Schlagworte
Markers
Ikzf1
Deletions
Results
Methods
Childhood
Alterations
Subsequent
Patients
Response
Quantification
Provide
Klinische Pädiatrie
