CareLit Fachartikel
Signatures of Mutational Processes in Childhood Cancers
SN Groebner, M Zapatka, RM Piro, SM Pfister · Klinische Pädiatrie · 2014 · Heft 05
Dokument
1113410
CareLit-ID
Jahr
2014
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Backgrounds: Most cancers arise as consequence of the accumulation of somatic mutations, including specific driver mutations and random passenger mutations. Both represent the imprint of different DNA damage and DNA repair processes interfering with the genome, which can also be referred to as mutational signatures. Methods: Recently, a method deciphering mutational signatures by modelling the underlying processes as a blind source separation problem was proposed and applied almost exclusively on adult cancers. Somatic mutations can be extracted from whole genome or whole exome next generation sequencing (WGS/WE…
Schlagworte
Signatures
Mutational
Cancers
Processes
Childhood
Mutations
Somatic
Including
Genome
Whole
Entities
Analysis
Klinische Pädiatrie
