Mice with point mutations in Ffar1 display impaired glucose tolerance

Aim: The fatty acid receptor 1 (FFAR1) is expressed in beta-cells and mediates fatty acid-dependent augmentation of GSIS. This feature led to the generation of specific FFAR1-agonists for the treatment of hyperglycaemia. Intriguingly, Ffar1 (-/-) mice were protected against liver steatosis, suggesting that antagonists of Ffar1 could have beneficial effects on metabolism. These opposing observations were made in genetically engineered, knockout and transgenic mice. However, compensatory and additional undetected changes due to the inserted expression system may influence the outcoming results in these mouse model…