Immune status is associated with the mode of delivery in infants at increased risk for Type 1 Diabetes
O D'Orlando, R Puff, A Henniger, S Krause, F Haupt, D Kühn, C Winkler, E Bonifacio, AG Ziegler · Diabetologie und Stoffwechsel · 2014 · Heft 05
Bibliografische Angaben
Zusammenfassung
Question: C-section is consistently associated with a higher risk for Type 1 Diabetes. To understand mechanisms, we investigated whether the mode of delivery: a) influences the distribution and activation status of immune cells; and b) effects immune responsiveness and cytokine profile during the first year of life. Methodology: Children at increased risk for Type 1 Diabetes born either by C-section or by Vaginal Delivery were included. Total numbers of white blood cells and the proportion of Treg, T cells, B cell subtypes, Neutrophils, Monocytes were examined by flow cytometry. CD4+ and CD8+ T cell proliferatio…
