The anti-inflammatory protein NUPR1 protects pancreatic islets from diabetogenic lipotoxic injury ex vivo
B Mihic-Necic, AE Mehana, C Liu, L Parsons, J Baumann, N Perakakis, K Laubner, J Seufert, G Päth · Diabetologie und Stoffwechsel · 2014 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background and aim: According to the so-called “nutrition overflow hypothesis”, type 2 diabetes results from nutrition-induced local tissue inflammation leading to insulin resistance, insulin secretory dysfunction and finally pancreatic β-cell loss. Free fatty acids (FFA) acting through toll-like receptors are key mediators of this lipotoxic inflammatory response. We previously demonstrated that the intracellular protein NUPR1 (p8) exerts potent anti-inflammatory and anti-diabetogenic effects in β-cells in vivo. Here we investigated the anti-lipotoxic potential of NUPR1 ex vivo in pancreatic islets of transgenic…
