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Gut bacteria and the development of diet-induced obesity: The role of dietary fiber and short-chain fatty acids

K Weitkunat, G Loh, KJ Petzke, M Blaut, S Klaus · Diabetologie und Stoffwechsel · 2014 · Heft 05

Dokument
1113428
CareLit-ID
Jahr
2014
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
K Weitkunat, G Loh, KJ Petzke, M Blaut, S Klaus
Ausgabe
Heft 05 / 2014
Seiten
–
Erschienen: 2014-05-06 00:00:00
ISSN
1861-9002
DOI
10.1055/s-0034-1375037

Zusammenfassung

The intestinal microbiota has recently been associated with the development of obesity and diabetes. Indeed, there is growing evidence that increased production of short-chain fatty acids (SCFAs) in the large intestine serves as an additional energy source, affecting whole-body energy metabolism. We aimed to examine the role of SCFAs in energy metabolism by using mice associated with a simplified human microbiota (SIHUMI). SIHUMI-mice received either a high fat diet with 10% cellulose (non-fermentable, HFC) or inulin (fermentable, HFI) for 6 weeks. We investigated energy balance, bacterial proliferation, and ana…

Schlagworte

Diet Obesity Dietary Fiber Cellulose Bacteria Acetate Diabetologie und Stoffwechsel