Glucose regulation during weight loss under dissociation of negative energy balance and changed body composition: preliminary data from an ongoing randomized controlled trial

Introduction: Weight loss is linked to metabolic benefits like improved glucose regulation. However, the impact of negative energy balance and changed body composition have not been investigated separately. Methods: 51 overweight/obese post-menopausal women were enrolled. The control group (CG: n = 26) remained weight stable over a period of 4 months. The intervention group (IG: n = 25) underwent a very low calorie (liquid and regular) diet (˜800 kcal/d) as well as nutrition counseling for 3 months (M3) and was subsequently kept weight stable for another month (M4). Phenotyping included assessment of body compos…