Mice with insulin resistance and non-alcoholic fatty liver are characterized by cardiac hypertrophy and increased oxidative stress

Non-alcoholic fatty liver (NAFL) and insulin resistance increase the risk of cardiac mortality and associate with impaired muscular and hepatic mitochondrial function. We hypothesized that also cardiac energy metabolism is altered in mice with insulin resistance and NAFL. Mice with adipose tissue-specific overexpression of the sterol regulatory-element binding protein-1c, which have lipodystrophy and develop NAFL (NAFL), and wild-type controls (CON), underwent hyperinsulinemic-euglycemic clamps to assess insulin sensitivity (IS, n = 5 – 7). Systolic blood pressure was measured with catheters introduced into the…