CareLit Fachartikel
Jagged-1 and Delta-like-4 stimulate the migration of B-lymphocytes
A Holzer, K Watzinger, CM Kaehler · Pneumologie · 2014 · Heft 05
Dokument
1113487
CareLit-ID
Jahr
2014
Publikation
PDF
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Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
The NOTCH pathway is an evolutionary conserved signaling pathway that is required for embryonic development and for maintenance of tissue homeostasis and stem cells in adults. Notch signaling is activated by interactions between Notch receptors (Notch 1 – 4) and their transmembrane ligands (Jagged-1, Jagged-2, Delta-like-1, Delta-like-2, Delta-like-4). Dysregulated Notch signaling is involved in different diseases like Alagille syndrom, spondylocostal dysostosis or several forms of cancer. From EDTA-anticoagulated venous blood, taken from healthy donors with their informed consent, B-cells were isolated using a…
Schlagworte
B-Lymphocytes
Alagille-Syndrom
Atmosphere
Cellulose
Germany
Blood
Pneumologie
