CareLit Fachartikel
Hepatitis C virus (HCV) genotypes – Are in the centre of antiviral therapy again (Analysis of HCV genotype distribution among Hungarian patients between 2000 – 2006 and 2009 – 201…
J Gervain · Zeitschrift für Gastroenterologie · 2014 · Heft 05
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1113492
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2014
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Background and Aims: HCV has great variability therefore it is classified into 6 different genotypes (1 – 6) based on the underlying genome structure. The corresponding difference in nucleotid sequence is 31 – 34%. Within each genotype one or more subtypes are differentiated (e.g. a, b, c), among these the nucleotid sequence difference is 20 – 23%. Since 2002, the guidelines of the National Institutes of Health and the American and European Association for Study of the Liver recommend compulsory genotype determination before the initiation of antiviral therapy. In our laboratory, the viral type distribution of H…
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Zeitschrift für Gastroenterologie
