Aberrant expression and activity of histone deacetylases (HDAC) in lungs of patients with sporadic idiopathic pulmonary fibrosis (IPF)
M Korfei, S Skwarna, I Henneke, O Klymenko, G Dahlem, S Ziegler, D von der Beck, W Klepetko, L Fink, W Seeger, O Krämer, A Guenther · Pneumologie · 2014 · Heft 06
Bibliografische Angaben
Zusammenfassung
Introduction: Histone deacetylases (HDACs) are enzymes that remove acetyl groups from an ε-N-acetyl lysine amino acid on histones, resulting in epigenetic repression of gene transcription. HDACs can also catalyze deacetylation of many non-histone proteins, such as the tumor suppressor p53, resulting in inhibition of its pro-apoptotic activity. HDACs thus pivotally control gene expression and cellular signaling. Due to their anti-apoptotic activity, HDACs are upregulated in many cancers. Here, we describe for the first time a biochemical characterization of Class-I/-II/-III-HDACs in lungs from patients with spora…
