Developing a score of early postoperative regulatory T cell frequency to predict bronchiolitis obliterans syndrome-free survival at two years after lung transplantation
J Salman, AK Knöfel, W Sommer, D Böthig, I Tudorache, M Avsar, F Ius, K Jansson, J Gottlieb, T Welte, A Haverich, G Warnecke · Pneumologie · 2014 · Heft 06
Bibliografische Angaben
Zusammenfassung
Introduction: Regulatory T cells (Treg) have potential to regulate alloantigens and thus may counteract the development of chronic rejection (i.e. bronchiolitis obliterans syndrome, BOS) in lung transplantation. BOS may affect over 60% of lung transplant recipients within five years. Here, we analyzed Tregs in peripheral blood of 120 lung recipients prospectively during the first 2 years and correlated with the onset of BOS at two years. Materials and Methods: In this study we detected circulating Treg by flow cytrometry in consecutive routine lung transplant recipients before transplantation 3 weeks, 3, 6, 12,…
