Autoantibodies to glycoprotein 2 are associated with the clinical phenotype in Crohn's disease
D Roggenbuck, DP Bogdanos, D Reinhold, U von Arnim, P Malfertheiner, A Forbes, K Conrad, M Laaß · Zeitschrift für Gastroenterologie · 2014 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background: Pancreatic antibodies (PAB) recognize zymogen granule glycoprotein 2 (GP2) as major autoantigenic target in patients with Crohn's disease (CD). Expression of GP2 has been demonstrated at the site of intestinal inflammation, explaining the previously unaddressed contradiction of pancreatic autoimmunity and intestinal inflammation. GP2 is a specific receptor on microfold (M) cells of intestinal Peyer's patches, which are considered to be the original site of inflammation in CD. Anti-GP2 IgA and IgG have been described as novel serological markers in CD. This study investigated the association of anti-G…
