CareLit Fachartikel
A diet containing wheat alpha-amylase/trypsin inhibitors (ATIs) promotes allergic airway inflammation in mice.
VF Zevallos, V Raker, J Maxeiner, M Khan, K Steinbrink, D Schuppan · Zeitschrift für Gastroenterologie · 2014 · Heft 08
Dokument
1113767
CareLit-ID
Jahr
2014
Publikation
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Zusammenfassung
Background: We have identified non-gluten components of wheat, alpha-amylase/trypsin inhibitors (ATIs), as potent activators of innate immunity by engaging the toll like receptor 4 (TLR4)-MD2-CD14 complex in monocytes, macrophages and dendritic cells. Nutritional ATIs are likely to be implicated in the pathogenesis of celiac disease (CD) as well as other autoimmune/inflammatory diseases. Objective To evaluate the effects of dietary ATIs on allergic airway inflammation in mice. Methods: Allergic airway inflammation was induced by ovalbumine (OVA) sensitisations and challenge in female C57BL/6 mice on a gluten-fre…
Schlagworte
Diet
After
Alpha-Amylase
Bronchoalveolar Lavage
Dendritic Cells
Cytokine
Zeitschrift für Gastroenterologie
