CareLit Fachartikel
Role of Protein Kinase D in colonic epithelial barrier function
R Sroka, T Eiseler, T Seufferlein · Zeitschrift für Gastroenterologie · 2014 · Heft 08
Dokument
1113770
CareLit-ID
Jahr
2014
Publikation
PDF
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Metadaten
DOI
ja
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Bibliografische Angaben
Zusammenfassung
Inflammatory bowel disease (IBD) is characterized by chronic inflammation of parts of the digestive tract. It causes debilitating symptoms including severe abdominal pain, diarrhea and sometimes even life-threatening complications. Chronic IBD is also assumed to be a direct cause of colitis-associated cancer (CAC). Colonic epithelial barrier function relies on the correct and stable formation of tight junctions to prevent infiltration of luminal antigens and enteric bacteria. Failure of barrier function results in intestinal inflammation by a complex network of immune interactions in the lamina propria, promotin…
Schlagworte
Cortactin
Caco-2 Cells
Abdominal Pain
Antigens
Bacteria
Diarrhea
Work
Actin
Zeitschrift für Gastroenterologie
