Loss of ATM accelerates KrasG12D – induced pancreatic cancer formation
R Russell, L Perkhofer, Q Lin, M Zenke, J Lennerz, T Seufferlein, M Wagner, A Kleger · Zeitschrift für Gastroenterologie · 2014 · Heft 08
Bibliografische Angaben
Zusammenfassung
Onset and progression of pancreatic ductal adenocarcinoma (PDAC) is associated with the accumulation of certain oncogenic mutations and more recently, genome-wide exome sequencing studies have identified ATM mutations in independent PDAC cohorts. However, the role of ATM is in PDAC initiation and progression is unclear. Here we report that conditional deletion of ATM in a mouse model of PDAC enhanced pancreatic cancer formation via induction of ductal reprogramming. Notably, there was an increase in tumour formation due to ATM haploinsufficiency. This resulted in a significantly shortened survival of AKC-mice co…
