Xenotransplantation of cryopreserved ovarian tissue: A realistic option for restoring fertility after cancer treatment?

Background: Xenografting of human ovarian tissue into mice has proved to be a useful model for examining ovarian function and follicle development in vivo. Moreover, with human follicles that have matured through xenografting, the possibility of cancer transmission and relapse can be eliminated, as cancer cells are not able to penetrate the zona pellucida. However it is speculated that ovarian xenotransplantation could be used for the production of fertilisable oocytes. Method: Cryopreserved human ovarian tissue from patients with different malignance was grafted into an intramuscular pocket of the neck muscle o…