Synchronous stage IA endometrial and ovarian carcinomas share common mutations: implications for tumour evolution and clinical staging
M Maaßen, M Anglesio, A Staebler, D Wallwiener, F Kommoss, M McConechy, A Karnezis, HL Chang, DG Huntsman, CB Gilks, S Brucker, FA Taran, S Kommoss · Geburtshilfe und Frauenheilkunde · 2014 · Heft 09
Bibliografische Angaben
Zusammenfassung
Introduction: Synchronous endometrial and ovarian carcinomas (SENOCA) are problematic due to a lack of objective criteria to define them as independent primary tumours or primary/metastasis pairs, a vital distinction for clinical staging and treatment. We sought to test whether these tumours have mutational profiles supporting independent or common origins. Methods: We identified 17 endometrioid SENOCA classified as independent stage IA primary tumours. Genomic DNA was extracted from germline and tumour tissues and next-generation sequencing across 34 genes frequently mutated in endometrial and/or ovarian tumour…
